Ovarian clear cell carcinoma (OCCC) is an uncommon subtype of epithelial ovarian carcinoma (EOC) that is often diagnosed at an earlier stage in younger women. Further larger, well-designed prospective studies are warranted to draw firmer conclusions on the intrinsic link between endometriosis and OCCC. Survival differences between the two groups were not significant after stratification analysis for independent prognosticators.ConclusionĮndometriosis was not independently associated with the prognosis of OCCC either in crude analysis or after stratification for stage and RD. The presence of endometriosis did not significantly affect either OS or PFS. There was no significant difference between the two groups regarding age (p-value = 0.2), FIGO stage (p-value = 0.8), residual disease (RD) (p-value = 0.07), adjuvant chemotherapy agent (p-value = 0.4) or chemo-resistance (p-value = 0.9). Clinico-pathological characteristics, progression-free survival (PFS) and overall survival (OS) were collated between the two groups.ResultsForty-six cases of endometriosis-free OCCC (Ef-OCCC) were collated with 48 cases of endometriosis-related OCCC (Er-OCCC). Women were divided into two groups according to the presence of endometriosis.

The aim of this study was to ascertain the effect of endometriosis on the prognosis of OCCC.MethodsA retrospective review of the medical records of 94 women diagnosed and treated for OCCC at a tertiary gynaecological cancer centre in the UK, spanning the period 2010–2019.

PurposeThe prognostic role of endometriosis amongst women with ovarian clear cell carcinoma (OCCC) remains debatable.

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